产品编号：T549002

产品规格：

产品价格：面议

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产品详情

标准品编号:	T549002
名称:	Tosedostat-d5
别名:	(αS)-α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic Acid-d5 Cyclopentyl Ester; CHR 2797-d5;
CAS号:	1217844-03-5
参考CAS号:	类似: 238750-77-1
分子式:	C₂₁H₂₅D₅N₂O₆
分子量:	411.5
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled Tosedostat. CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacological active acid product (CHR-79888) inside cells. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity for transformed over nontransformed cells. Its antiproliferative effects are at least 300 times more potent than the prototypical aminopeptidase inhibitor, Bestatin.
参考文献	Sato, Y., et al.: Biol. Pharm. Bull., 27, 772 (2004), Saveanu, L., et al.: Nat. Immunol., 6, 689 (2005), Proud, C., et al.: Biochem. J., 403, 217 (2007), Watatani, Y., et al.: Life Sci., 80, 879 (2007),