产品编号：V787500
产品规格：100mg
产品价格：面议
| 标准品编号: | V787500 |
| 名称: | VU 0357017 Hydrochloride |
| 别名: | 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride; |
| CAS号: | 1135242-13-5 |
| 参考CAS号: | Free Base: 1135681-23-0 |
| 分子式: | C₁₈H₂₈ClN₃O₃ |
| 分子量: | 369.89 |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model. |
| 参考文献 | |
