产品编号：U822000
产品规格：10mg
产品价格：面议
| 标准品编号: | U822000 |
| 名称: | URB754 |
| 别名: | 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one; |
| CAS号: | 86672-58-4 |
| 分子式: | C₁₆H₁₄N₂O₂ |
| 外观: | 白色至白色固体 |
| 熔点: | >202°C (dec.) |
| 分子量: | 266.29 |
| 储存: | 冰箱 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly, Heated) |
| 类别: | Research Tools; Enzyme Activators and Inhibitors; |
| 应用: | URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management. |
| 参考文献 | |
