产品编号：U700585

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	U700585
名称:	UK-356618
别名:	(2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide; UK 356618;PF-03890101;
CAS号:	230961-08-7
分子式:	C₃₄H₄₃N₃O₄
外观:	Beige Solid
熔点:	93-102ºC
分子量:	557.72
储存:	-20˚C Freezer
溶解度:	Methanol (Slightly)
类别:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
参考文献	Fray, M.J. et al.: Bioorg. Med. Chem. Lett., 11, 571 (2001); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003);