产品编号：T876500
产品规格：2.5mg
产品价格：面议
| 标准品编号: | T876500 |
| 名称: | (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid |
| CAS号: | 193146-63-3 |
| 分子式: | C₄₅H₈₅NO₆SSi₃ |
| 外观: | Off-White Sticky Foam |
| 分子量: | 852.48 |
| 溶解度: | Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate |
| 类别: | Standards; Chiral Molecules; |
| 应用: | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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