产品编号：T296000

产品规格：1g

产品价格：面议

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产品详情

标准品编号:	T296000
名称:	1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one
别名:	1-(4-Amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS号:	137977-97-0
分子式:	C₁₈H₁₇ClN₂O₂
外观:	白色至淡黄色固体
熔点:	186-189°C
分子量:	328.79
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
类别:	Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.
参考文献	Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999); Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)