产品编号：P294450

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	P294450
名称:	PHA 767491 Dihydrochloride Salt
别名:	1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471;
参考CAS号:	freebase: 845714-00-3942425-68-5 -for HCl
分子式:	C₁₂H₁₃Cl₂N₃O
外观:	淡黄色固体
熔点:	>269ºC (dec.)
分子量:	286.16
储存:	Hygroscopic, 冰箱, under inert atmosphere
溶解度:	Chloroform, DMSO, Water
稳定性:	Hygroscopic
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).
参考文献	Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);