产品编号：P216400

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	P216400
名称:	PCI-24781
别名:	3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; CRA 024781; CRA 24781;
CAS号:	783355-60-2
分子式:	C₂₁H₂₃N₃O₅
外观:	白色固体
熔点:	198-202ºC (dec.)
分子量:	397.42
储存:	冰箱
溶解度:	DMSO (Slightly), Methanol (Slightly, Heated)
类别:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
参考文献	Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000), Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2005), Esteller, M., et al.: Carcinogenesis, 27, 1121 (2006),