产品编号：P132002
产品规格：25mg
产品价格：面议
| 标准品编号: | P132002 |
| 名称: | PAC-1-d8 |
| 别名: | 4-(Phenylmethyl)-1-(piperazine-d8)acetic Acid (2E)-2-[[2-Hydroxy-3-(2-propen-1-yl) phenyl]methylene]hydrazide; |
| CAS号: | 1287241-26-2 |
| 参考CAS号: | 1044929-62-5-unlabelled |
| 分子式: | C₂₃H₂₀D₈N₄O₂ |
| 外观: | 白色固体 |
| 熔点: | 129-131°C |
| 分子量: | 400.54 |
| 储存: | 冰箱, Under Inert Atmosphere |
| 溶解度: | DMSO, Methanol |
| 类别: | Research Tools; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
| 危险品: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考文献 | |
