产品编号：M320350
产品规格：10mg
产品价格：面议
| 标准品编号: | M320350 |
| 名称: | N-Methyl Naltrexone Bromide |
| 别名: | (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; Methylnaltrexone; Methylnaltrexone Bromide; N-Cyclopropylmethyl-noroxymorphone Methobromide; N-Methylnaltrexone Bromide; Naltrexone Methyl Bromide; Naltrexone Methobromide; Relistor; MRZ 2663BR; |
| CAS号: | 73232-52-7 |
| 分子式: | C₂₁H₂₆BrNO₄ |
| 外观: | Pale Pink to Pale Brown Solid |
| 熔点: | >237°C (dec.) |
| 分子量: | 436.34 |
| 储存: | Hygroscopic, -20˚C Freezer, Under Inert Atmosphere |
| 溶解度: | DMSO (Slightly), Methanol (Slightly) |
| 种类: | Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; Opiates; Natural Products; |
| 应用: | A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. |
| 危险品: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考文献 | |
