产品编号：L486640

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	L486640
名称:	LY 311727
别名:	P-[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]phosphonic Acid; [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]phosphonic Acid; [3-[[3-(Amidomethyl)-2-ethyl-1-(phenylmethyl)indol-5-yl]oxy]propyl]phosphonic Acid
CAS号:	164083-84-5
分子式:	C₂₂H₂₇N₂O₅P
分子量:	430.43
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	LY 311727 is an inhibitor of secretory phospholipase A2 (sPLA2) and can be used to block Pseudomonas aeruginosa cytotoxicity. It can also attenuate VEGF-mediated platelet-activating factor (PAF) synthesis in HUVEC and BAEC cells.
参考文献	Phillips, R., et al.: J. Biol. Chem., 278, 41326 (2003); Buitrago-Rey, R., et al.: J. Antimicrob. Chemoth., 49, 871 (2002); Schevitz, R.W., et al.: Nat. Struct. Biol., 2, 458 (1995); Fleisch, J.H. et al.: J. Pharmacol. Exp. Ther., 278, 252 (1996); Bridonneau, P., et al.: J. Med. Chem., 41, 778 (1998); Bidgood, M.J. et al.: J. Immunol., 165, 2790 (2000); Bernatchez, P.N., et al.: Br. J. Pharmacol., 134, 197 (2001)