产品编号：L469465

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	L469465
名称:	Lometrexol Hydrate
别名:	N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid Hydrate; LY 264618 Hydrate;
参考CAS号:	Anhydrous: 106400-81-1
分子式:	C₂₁H₂₅N₅O₆ • xH ₂O
分子量:	443.451802
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.
危险品:	Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
参考文献	Gibbs, D., et al.: Cancer Res., 65, 11721 (2005), Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005), Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005),