产品编号：L321002

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	L321002
名称:	LEE011-d6
别名:	7-Cyclopentyl-N,N-di(methyl-d3)-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS号:	1328934-40-2
参考CAS号:	Unlabelled: 1211441-98-3
分子式:	C₂₃H₂₄D₆N₈O
分子量:	440.57
种类:	Building Blocks; Isotopic Labeled Analogues;
应用:	LEE011-d6 is the isotope analog of LEE011(L321000). LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
参考文献	Kim, S., et al.: Mol. Cancer Ther., 12, PR02 (2013); Rader, J., et al.: Clin. Cancer Res., 19, 6173 (2013)