产品编号：L321000
产品规格：10mg
产品价格：面议
| 标准品编号: | L321000 |
| 名称: | LEE011 Succinate |
| 别名: | 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate |
| CAS号: | 1374639-75-4 |
| 参考CAS号: | 1211441-98-3 free base |
| 分子式: | C₂₇H₃₆N₈O₅ |
| 外观: | Pale Beige Solid |
| 熔点: | >160ºC (dec.) |
| 分子量: | 552.63 |
| 储存: | 冰箱 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly) |
| 种类: | Research Tools; Enzyme Activators and Inhibitors; |
| 应用: | LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. |
| 参考文献 | |
