产品编号：K659500

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	K659500
名称:	KRN 633
别名:	1-(2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-propylurea
CAS号:	286370-15-8
分子式:	C₂₀H₂₁ClN₄O₄
外观:	白色固体
熔点:	231-232°C
分子量:	416.86
储存:	-20°C Freezer
溶解度:	Chloroform (Slightly, Heated), DMSO (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
参考文献	Fediriv, O., et al.: Proc. Natl. Acad. Sci. USA, 104, 20523 (2007); Nakamura, K., et al.: Mol. Cancer. Ther., 3, 1639 (2004)