产品编号：I941800

产品规格：100mg

产品价格：面议

---

产品详情

标准品编号:	I941800
名称:	IWR-1
别名:	rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;
CAS号:	1127442-82-3
分子式:	C₂₅H₁₉N₃O₃
分子量:	409.44
种类:	Research Tools;
应用:	IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
参考文献	Lepourcelet, M., et al.: Cancer Cell., 5, 91 (2004), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),