产品编号：I882200
产品规格：25mg
产品价格：面议
| 标准品编号: | I882200 |
| 名称: | 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride |
| 别名: | HA1077, Fasudil Dihydrochloride; |
| CAS号: | 203911-27-7 |
| 参考CAS号: | Free Base: 103745-39-7 |
| 分子式: | C₁₄H₁₉Cl₂N₃O₂S |
| 外观: | 白色至白色固体 |
| 熔点: | >238ºC (dec.) |
| 分子量: | 364.28 |
| 储存: | -20°C Freezer |
| 溶解度: | Methanol (Slightly), Water (Slightly) |
| 种类: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM). |
| 参考文献 | |
