产品编号：I706325
产品规格：30mg
产品价格：面议
| 标准品编号: | I706325 |
| 名称: | 1-(1-iodoethyl)-4-octylbenzene |
| 别名: | Fingolimod Impurity 10 |
| 分子式: | C₁₆H₂₅I |
| 分子量: | 344.27 |
| 种类: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | 1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
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