产品编号：H949834

产品规格：2.5mg

产品价格：面议

---

产品详情

标准品编号:	H949834
名称:	10-Hydroxy-11-methoxycamptothecin-d3
分子式:	C₂₁H₁₅D₃N₂O₆
分子量:	397.4
种类:	Standards; Isotopic Labeled Analogues;
应用:	10-Hydroxy-11-methoxycamptothecin-d3 is the labelled version of 10-Hydroxy-11-methoxycamptothecin (H949833) which can be obtained from (S)-(+)-Camptothecin (C175150) which is an antitumor alkaloid. It binds irreversible to the DNVIP(LA)topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
参考文献	Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998)