产品编号：G411813

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	G411813
名称:	GLPG1690
别名:	2-[[2-Ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)-5-thiazolecarbonitrile; GLPG-1690
CAS号:	1628260-79-6
分子式:	C₃₀H₃₃FN₈O₂S
分子量:	588.7
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	GLPG1690 is a selective autotaxin inhibitor discovered by Galapagos, with potential application in idiopathic pulmonary disease (IPF). In a Phase 1 study in healthy human volunteers, GLPG1690 demonstrated favorable safety and tolerability, as well as a strong pharmacodynamic signal implying target engagement.
参考文献	Desroy, Nicolas., et al.:J Med Chem., 60,3580 (2017); Nikolaou, Aikaterini., et al.: J Med Chem.,61,3697 (2018); Kuttruff, Christian A., et al.: ACS Med Chem Lett., 8,1252(2017)