产品编号：F595000
产品规格：2.5g
产品价格：面议
| 标准品编号: | F595000 |
| 名称: | 5-Fluoroorotic Acid Monohydrate (Ultra Pure) |
| 别名: | 5-FOA |
| CAS号: | 220141-70-8 |
| 参考CAS: | 703-95-7 |
| 分子式: | C₅H₅FN₂O₅ |
| 外观: | Must be 白色固体 |
| 熔点: | >255°C (dec.) |
| 分子量: | 192.1 |
| 储存: | -20°C Freezer |
| 溶解度: | Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl |
| 种类: | Research Tools; Molecular Biology; |
| 应用: | 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in |
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