产品编号：E679570

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	E679570
名称:	Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
别名:	4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid Ethyl Ester
CAS号:	536759-91-8
分子式:	C₂₂H₂₀N₄O₆
外观:	Light Orange Solid
熔点:	190-192°C
分子量:	436.42
储存:	冰箱保存
溶解度:	Chloroform (Slightly), Ethyl Acetate (Slightly)
种类:	Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an intermediate in the synthesis of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
参考文献	Pinto, D.J.P., et. al.: J. Med. Chem., 50, 5339 (2007); Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)