产品编号：E589002
产品规格：2.5mg
产品价格：面议
| 标准品编号: | E589002 |
| 名称: | Epothilone D-13C2,15N |
| 别名: | (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione-13C2,15N; (-)-Desoxyepothilone B-13C2,15N; (-)-Epothilone D-13C2,15N; 12,13-Deoxyepothilone B-13C2,15N; 12,13-Desoxyepothilone B-13C2,15N; Desoxyepothilone B-13C2,15N; Epo D-13C2,15N; Epothilone D-13C2,15N; KOS 862-13C2,15N; NSC 703147-13C2,15N; |
| 参考CAS: | 未标记：189453-10-9 |
| 分子式: | C₂₅¹³C₂H₄₁¹⁵NO₅S |
| 分子量: | 494.66 |
| 种类: | Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Epothilone D-13C2,15N is the isotopically labelled form of synthetic Epothilone D (E589000), which is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones polyketide natural products. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. Epothilone D is in phase I of clinical testing in patients with advanced solid tumours. |
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