产品编号：E588913

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	E588913
名称:	Eplerenone 3,20-Bis-ethyl Enol Ether
别名:	(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 2,5'-Diethoxy-4a,6a-dimethyl-4,4a,5a,6,6a,8,9,9a,9b,10-decahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
分子式:	C₂₈H₃₈O₆
外观:	Oil
分子量:	470.6
溶解度:	Chloroform; Methanol
种类:	Standards; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Eplerenone 3,20-Bis-ethyl Enol Ether is an intermediate in synthesizing 6β,21-Dihydroxy-Eplerenone (E588750). Eplerenone (E588775) is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
参考文献	de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987); Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001); Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004); Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005)