产品编号：D534250

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	D534250
名称:	Doramapimod
别名:	N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796;
CAS号:	285983-48-4
分子式:	C₃₁H₃₇N₅O₃
外观:	Pale Beige Solid
熔点:	>136°C (dec.)
分子量:	527.66
储存:	冰箱保存
溶解度:	DMSO, Methanol
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.
参考文献	Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);