产品编号：D474165

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	D474165
名称:	(1R,​2S)​-2-​[3-​[(1E)​-​2-​[4-​[[(2R,​6S)​-​2,​6-​Dimethyl-​4-​morpholinyl]​methyl]​phenyl]​ethenyl]​-​1H-​indazol-​6-​yl]​-​5'-​methoxy-​spiro[cyclopropane-​1,​3'-​[3H]​indol]​-​2'(1'H)​-​one
CAS号:	1338806-73-7
分子式:	C₃₃H₃₄N₄O₃
分子量:	534.65
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	(1R,​2S)​-2-​[3-​[(1E)​-​2-​[4-​[[(2R,​6S)​-​2,​6-​Dimethyl-​4-​morpholinyl]​methyl]​phenyl]​ethenyl]​-​1H-​indazol-​6-​yl]​-​5'-​methoxy-​spiro[cyclopropane-​1,​3'-​[3H]​indol]​-​2'(1'H)​-​one selectively inhibits polo-like kinase 4 (PLK4), which is a serine/threonine protein kinase that regulates centriole duplication during the cell cycle. PLK4 is a therapeutic target for various cancers.
参考文献	Sredni, S. T., et al.: Pediatr Blood Cancer. e26551 (2017); Sampson, P. B., et al.: J Med Chem. 58, 147 (2015)