产品编号：D297840

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	D297840
名称:	N-(Destriazolonomethyl) N-(Methylcarboxyacetamidohydrazono) Aprepitant
别名:	Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)-1-iminoethyl)hydrazinecarboxylate;
CAS号:	219821-37-1
分子式:	C₂₄H₂₅F₇N₄O₄
分子量:	566.47
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-(Destriazolonomethyl), N-(Methylcarboxyacetamidohydrazono) Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.
参考文献	Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),