产品编号：B807090

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	B807090
名称:	tert-Butyl 6-Cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate Hydrochloride
别名:	6-​Cyano-​2-​[1-​[4-​ethyl-​3-​[4-​(4-​morpholinyl)​-​1-​piperidinyl]​phenyl]​-​1-​methylethyl]​-​1H-​Indole-​3-​carboxylic Acid 1,​1-Dimethylethyl Ester Hydrochloride;
CAS号:	1256584-77-6
参考CAS:	Free Base: 1256698-41-5
分子式:	C₃₄H₄₄N₄O₃ • (HCl)
分子量:	556.743646
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	tert-Butyl 6-Cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate Hydrochloride is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
参考文献	Jiang, X. et al.: Eur. J. Med. Chem., 105, 39 (2015); Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);