产品编号：B677393

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	B677393
名称:	Brilanestrant
别名:	E)-3-[4-[(E)-2-(2-Chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl]phenyl]-2-propenoic Acid; (E)-3-[4-[(E)-2-(2-Chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl]phenyl]acrylic Acid: ARN 810; GDC 0810; RG 6046; RO 7056118
CAS号:	1365888-06-7
分子式:	C₂₆H₂₀ClFN₂O₂
分子量:	446.9
类别:	Research Tools; Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Brilanestrant is an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer.
参考文献	Lai, Andiliy., et al.: J Biol Chem.,Â58,Â4888 (2015);McDonnell, Donald P., et al.: J Biol Chem., Â58,Â4883 (2015); ÂGovek, Steven P., et al.: Bioorg Med Chem Lett.,Â25,Â5163 (2015)