Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Epothilone D-13C2,15N is the isotopically labelled form of synthetic Epothilone D (E589000), which is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones polyketide natural products. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. Epothilone D is in phase I of clinical testing in patients with advanced solid tumours.
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