E 7449_1140964-99-3_E102500_【莱耀标准品网】

产品基本信息

产品编号：E102500

产品名称：E 7449

产品CAS：1140964-99-3

规格含量：5mg

产品价格：面议

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产品详细介绍

标准品编号:	E102500
名称:	E 7449
别名:	8-[(1,3-Dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one;
CAS号:	1140964-99-3
分子式:	C₁₈H₁₅N₅O
分子量:	317.34
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCVIP(LA)deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively.
参考文献	McGonigle, S., et al.: Oncotarget. 6, 41307 (2015)

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