(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentene-1-methanol; USP Abacavir Related Compound A; Abacavir EP Impurity C; Abacavir Related Compound A; Abacavir Impurities; Abacavir Intermediates
杂质:
Abacavir EP Impurity C; Abacavir USP Related Compound A
CAS号:
124752-25-6
分子式:
C₁₁H₁₄N₆O
外观:
白色至淡黄色固体
熔点:
177-179ºC
分子量:
246.27
储存:
-20ËšC Freezer
溶解性:
DMSO (Slightly), Methanol (Slightly, Heated)
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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