4,4-Difluorocyclohexanone is a useful synthetic intermediate. It is used to prepare cyclohexyl fluoropyrimidinyl benzamides as CNS penetrable P2X7 receptor antagonists. It is also used to prepare 3-(5-arylbenzimidazol-2-yl)-1-oxa-2-azaspiro[4.5]decenes as transient receptor potential melastatin 8 antagonists.
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