Building Blocks; Chiral Molecules; Isotopic Labeled Analogues;
应用:
(+)-(1R,2R,5R)--Ethyl [(2-Hydroxypinan-3-ylene)amino]acetate-13C2 is an intermediate in the synthesis of D-erythro-Sphingosine-1-phosphate-13C2,D2 (S681502), which is a labelled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes; mobilizes intracellular calcium stores; decreases cellular cAMP; activates phospholipase D; does not inhibitprotein kinase C.
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