2,4,5-Trihydroxy-L-phenylalanine; 2,4,5-Trihydroxyphenylalanine; 2,5-Dihydroxy-L-tyrosine; 3-(3,4,6-Trihydroxyphenyl)-L-alanine; 6-Hydroxy-L-DOPA; Hydroxy-L-dopa; L-6-Hydroxydopa; TOPA; Levodopa EP Impurity A; Levodopa USP Related Compound A
杂质:
Levodopa EP Impurity A; Levodopa USP Related Compound A
CAS号:
27244-64-0
分子式:
C₉H₁₁NO₅
外观:
Grey to Brown Solid
熔点:
>190°C (dec.)
分子量:
213.19
储存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:
Water (Slightly)
种类:
Standards; Amino Acids; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.
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