1-(2,3-Dihydroxy-4-methoxyphenyl)ethanone Hydrate is a hydrated form of 1-(2,3-Dihydroxy-4-methoxyphenyl)ethanone(D481100); a neuroprotective compound isolated from Cynenchum paniculatum, that exerts neuroprotective and cognitive-enhancing activities through its antioxidant activity and may be helpful for the treatment of Alzheimer's disease.