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| 产品基本信息 |
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| 产品编号：D474245 |
| 产品名称：(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Es |
| 产品CAS：168958-19-8 |
| 规格含量：25mg |
| 产品价格：面议 |
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| 产品详细介绍 |
| 标准品编号: |
D474245 |
| 名称: |
(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester |
| 别名: |
(1R-trans)--4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester; (R)-t-Butyl (3-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate; |
| CAS号: |
168958-19-8 |
| 分子式: |
C₁₂H₁₉NO₄ |
| 分子量: |
241.28 |
| 储存: |
Room Temperature, under inert atmosphere |
| 溶解性: |
Methanol |
| 种类: |
Building Blocks; Nucleic Acid; Carbohydrates; |
| 应用: |
(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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![(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Es](/uploads/allimg/191126/1_112614523SP6.png "(1R,4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Es")
