(1aS,8R,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; [1aS-(1aα,8β,8aα,8bα)]-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; BMY 25067; N-7-(2-Nitrophenyldithio)ethyl)mitomycin C
CAS号:
95056-36-3
分子式:
C₂₃H₂₅N₅O₇S₂
分子量:
547.6
类别:
Standards; Antibotics;
应用:
BMS 181174 is an analog of Mitomycin C (M371900) with activity against a range of tumour cell lines and xenografts, including MMC-resistant tumours. However, phase I clinical trials from Bristol-Myers Squibb demonstrated that the toxicity profile of BMS 181174 was no more favourable than that of mitomycin.