Bisindolylmaleimide II_137592-45-1_B448535

产品基本信息

产品编号：B448535

产品名称：Bisindolylmaleimide II

产品CAS：137592-45-1

规格含量：2.5mg

产品价格：面议

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产品详细介绍

标准品编号:	B448535
名称:	Bisindolylmaleimide II
别名:	3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
CAS号:	137592-45-1
分子式:	C₂₇H₂₆N₄O₂
分子量:	438.52
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	Bisindolylmaleimide II, is a potent ATP-competitive protein kinase C (PKC) inhibitor. In addition it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM).
文献	Davis, P.D. et al.: Journal of Medicinal Chemistry 35, 177-184 (1992); Komander D. et al.: Structure 12, 215-226 (2004);

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