N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide; Abacavir - In House Impurity; Abacavir Impurities
杂质:
Abacavir - In House Impurity
CAS号:
171887-03-9
分子式:
C₅H₄Cl₂N₄O
状态：
灰白色至浅褐色固体
熔点：
>251°C (dec.)
分子量:
207.02
储存：
Amber Vial, 冰箱保存, Under inert atmosphere
溶解性:
DMSO, Methanol
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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