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产品基本信息
产品编号：D470930
产品名称：17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride
产品CAS：467214-21-7
规格含量：25mg
产品价格：面议
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产品详细介绍
标准品编号:
D470930
名称:
17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride
别名:
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride;
CAS号:
467214-21-7
参考CAS号:
467214-20-6-free base
分子式:
C₃₂H₄₉ClN₄O₈
外观:
Very Dark Purple Solid
熔点:
>270°C (dec.)
分子量:
653.21
储存:
-20˚C Freezer
溶解性:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
参考文献
Dote, H. et al.: Cancer Res., 66, 9211 (2006); Smith, V. et al.: Cancer Chemother. Pharmacol., 56, 126 (2005); Egorin, M.J. et al.: Cancer Chemother. Pharmacol., 49, 7 (2002);
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