2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-O-succinate is a nucleoside used in the synthetic preparation of DNA fragments, such as small-molecule/DNA hybrids via amide coupling. 2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-O-succinate can also be used as a solid phase support for oligonucleotide synthesis.