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产品基本信息
产品编号：D230750
产品名称：Demecolceine
产品CAS：518-11-6
规格含量：50mg
产品价格：面议
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产品详细介绍
标准品编号:
D230750
名称:
Demecolceine
别名:
(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; 7-Deacetamido-7-(methylamino)colchiceine; N-Desacetyl-N-methylcolchiceine; NSC 36559;
CAS号:
518-11-6
分子式:
C₂₀H₂₃NO₅
外观:
Yellow Solid
熔点:
120-122°C
分子量:
357.4
储存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Chloroform (Slightly), Methanol (Slightly, Heated)
种类:
Standards; Enzyme Activators and Inhibitors;
应用:
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献
Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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