6-Chloro-9-((2S,3R)-2-(diethoxymethoxy)nonan-3-yl)-9H-purine is an intermediate in the synthesis of rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt (H825550), which is a potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does not inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Potent PDE-2 inhibitor.
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