(1S-cis)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Monohydrochloride; Abacavir USP Related Compound C USP; Abacavir Related Compound C; Abacavir Impurities; Abacavir Intermediates; Abacavir USP RC C
杂质:
Abacavir USP Related Compound C
CAS号:
172015-79-1
备用CAS:
Free Base: 136522-33-3
分子式:
C₁₁H₁₃Cl₂N₅O
状态：
白色至Beige to Brown Solid
熔点：
>154°C (dec.)
分子量:
302.16
储存：
冰箱保存, Under Inert Atmosphere
溶解性:
DMSO (Slightly), Methanol (Slightly)
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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