F-CPR-II CEP allows a combination of fluorous affinity purification with concomitant 5'-phosphorylation, which is especially attractive when synthesizing longmers that will be used in ligase reactions. It may also be utilized as a common handle for fluorous purification, obviating the need to choose a different fluorous phosphoramidite for each different 5'-terminal nucleotide when a 5'-phosphate is tolerated in a particular application.
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