Standards; Environmental Standards, Mutagens and Metabolites; Nicotine Derivatives and Metabolites;
应用:
(R)-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is the R-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which is a major metabolite of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (M325750). It is a tobacco specific N-nitrosamine (TSNA) and a potent pulmonary carcinogen. The R-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, (R)-NNAL, tends to be significantly more tumorigenic than the S-entiomer, (S)-NNAL.
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