19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoic Acid; (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic Acid; Antibiotic CI 940; Antibiotic CL 1957A; CI 940; CL 1957A; Elactocin; Mantuamycin; NSC 364372; PD 114720;
CAS号:
87081-35-4
分子式:
C₃₃H₄₈O₆
外观:
白色至淡黄色固体
熔点:
>56°C (dec.)
分子量:
540.73
储存:
-20°C Freezer, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Leptomycin B is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. It covalently binds to cysteine residue in the center of CRM1/exportin 1 protein.
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