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| 产品基本信息 |
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| 产品编号：H942223 |
| 产品名称：N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic |
| 产品CAS：168960-18-7 |
| 规格含量：250mg |
| 产品价格：面议 |
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| 产品详细介绍 |
| 标准品编号: |
H942223 |
| 名称: |
N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester |
| 别名: |
(1R-cis)-[4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester; [(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester |
| CAS号: |
168960-18-7 |
| 分子式: |
C₁₁H₁₉NO₃ |
| 外观: |
Yellow Oil |
| 分子量: |
213.27 |
| 溶解度: |
DMSO; Methanol |
| 种类: |
Building Blocks; Miscellaneous; |
| 应用: |
N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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![N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic](/images/defaultpic.gif "N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic")
