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产品编号：F621098
产品名称：Fluorogenic Proteasome Substrate Substrate
产品CAS：141223-71-4
规格含量：10mg
产品价格：面议
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产品详细介绍
标准品编号:
F621098
名称:
Fluorogenic Proteasome Substrate Substrate
别名:
N-[(Phenylmethoxy)carbonyl]-L-valyl-L-lysyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-methioninamide; 1: PN: WO2008077109 PAGE: 7 claimed sequence
CAS号:
141223-71-4
分子式:
C₃₄H₄₅N₅O₇S
分子量:
667.82
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Fluorogenic Proteasome Substrate (Z-VKM-AMC) is used to measure the peptidase activity of the 20S proteasome. Also used as a fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes. AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
参考文献
1. Ishiura, S., et al., 1990. Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue. Neuroscience letters. 115(2-3): 329-34. PMID: 2234509 2. Koike, H., et al., 1999. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. Journal of biochemistry. 126(1): 235-42. PMID: 10393344 3. Matsui, Hitoshi., et al., 2002. Presence of angiotensin-converting enzyme in follicular fluids of porcine ovaries and its possible involvement in the intrafollicular breakdown of bradykinin. Molecular reproduction and development. 62(1): 99-105. PMID: 11933166 4. Hook, Vivian Y H., et al., 2002. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolyti
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